Abstract:As a national strategy, the regional integration in the Yangtze River Delta is urgent to improve the regional collaborative innovation system, fight to be the pioneer of sci-tech and innovation industry, and strive to become an important source of innovation in the whole country. Thereinto, how to accelerate the industrialization of innovative scientific and technological achievements through the deep and effective integration of the innovation chains and the industrial chains, converge the innovative forces of industry, university and research, and fundamentally eliminate the problem of "two skins" in the science and technology economy is one of the effective solutions for the Yangtze River Delta to consolidate its core competitiveness and participate in international competition and cooperation on behalf of the country. Thus, this article first analyzes the integration and development status of sci-tech and innovation industries across various cities in the Yangtze River Delta. Next, taking the integrated circuit (IC) industry as an example, the article focuses on the integration trend of the sci-tech and innovation industry and outlines the industrial base and advantages. It also sorts out the weaknesses in the industrial chain, and addresses the problems in the industrial chain, as well as the future suggestions for development. Finally, a corresponding path model is proposed for the integrated development of the overall sci-tech and innovation industry in the Yangtze River Delta.